The Buzz

If you pay any attention at all to the alternative-health information-grapevine, you’ve heard the buzz on ellagic acid. If you believe the rumors flying around the Internet, the cure for cancer is at hand!! This is the greatest discovery since sliced bread!! Well, like most rumors, there’s some truth to it…and a whole lot of nonsense


The Truth

Two years ago, I wrote in the Barron Report on antioxidants about the value of including berries in your diet because of the benefits of the ellagic acid derived from them. This recommendation was based on work being done at the Hollings Cancer Institute by Dr. Daniel Nixon, who had been studying the benefits of red raspberries for some 6 years at that time. Since then, two things have changed dramatically.

q       First, the study results are now becoming, for lack of a better word, remarkable.

q       Second, it is now possible to get high quantities of ellagitannins without having to consume a cup of berries every day.

Dr. Nixon’s published results show:

q       Consuming one cup of red raspberries per day (40 mg of ellagitannins) prevents the development of cancer cells. At low concentrations it slows the growth of cancer cells; at higher concentrations, it tells cancer cells to kill themselves. For example, cells infected with the human papilloma virus (which is linked to cervical cancer), when exposed to ellagic acid experienced apoptosis, or normal cell death.

q       Red raspberry ellagitannins slow the growth of abnormal colon cells in humans

q       Tests reveal similar results for breast, pancreas, esophageal, skin, and prostate cancer cells. The ellagitannins also produce a breakdown in human leukemia cells.

q       Another way that ellagitannins protect your body is through G-Arrest. G-Arrest means that the ellagitannins stop cells from mutating in the first place. If cells don’t mutate, then we don’t get cancer. This is very important when you understand that that every single day of your life you produce anywhere from a few hundred to as many as 10,000 cancerous cells in your body as part of your normal metabolism. In tests conducted by the Hollings Cancer Institute with Ellagic Acid, G-Arrest began in 72 hours in both breast and cervical cancer.

q       Red raspberry ellagitannins prevent destruction of the P53 gene by cancer cells.  P53 prevents mutagenic activity in cervical cells.

q       Red raspberry ellagitannins protect human cells against cancer-causing agents in tobacco smoke, food additives, and petroleum-based substances. Ellagitannins act as scavengers to “bind” cancer-causing chemicals, making them inactive. The ellagitannins inhibit the ability of other chemicals to cause mutations in bacteria. Red Raspberry ellagitannins also protect DNA by blocking carcinogens from binding to the DNA.

q       European medical studies also demonstrate that red raspberry ellagitannins lower the incidence of birth defects, promote wound healing, reduce heart disease, and may reduce or reverse chemically induced liver fibrosis. In addition, the ellagic acid produced from the ellagitannins has anti-bacterial and anti-viral properties

Apoptosis

The problem with cancer cells is that when they divide, the original cell does not die.

The normal process of cell division, on the other hand, results in the replicating cell being “carried off” as trash just as if a bacterium had died. The body signals the dismantling of the old cell and the new cell takes over its processes. This is called apoptosis, or natural cell death.

Cancer cells, as mentioned above, are different. Cancer cells do not die; they rapidly multiply by cell division (mitosis), making 2 cancer cells, then 4, 8, 16, 32 and so on. What Dr. Nixon found is that in both lab and clinical studies, red raspberry ellagitannins caused cancer cells to go through a nontoxic, normal apoptosis process without damaging the healthy cells. This is a remarkable improvement over standard treatments.

Chemotherapy and radiation do the same thing – kill cancer cells, that is. But they have a devastating side effect that does not happen with the ellagitannins: they kill healthy cells too --  destroying the immune system in the process. More people probably die from the side effects of chemo and radiation than actually die from the original cancer.

This is why Dr. Nixon’s studies on ellagitannins are so exciting. Potentially, we’re talking about an all-natural cancer treatment/preventative that provides ALL of the benefits of chemo and radiation and NONE OF THE SIDEFFECTS. An all-natural supplement, if you will, that can literally be taken every single day to prevent most cancers from ever even forming in your body.

Enough of the Nonsense

Ellagic acid supplements are now appearing everywhere, and most of them are pure nonsense. As for those products that truly contain pure ellagic acid, you don’t want them.

q       First of all, ellagic acid doesn’t work as well as the complete ellagitannin complex. Although ellagic acid alone has been shown to inhibit carcinogenesis both in vivo and in vitro, several studies have reported that the other phenolic compounds in the berries also contribute to the observed inhibitory effect. Those compounds are only present in a complete ellagitannin complex, not in a synthetic ellagic acid isolate. In other words, an ellagitannin complex works better than pure ellagic acid

q       Second, synthetic ellagic acid is too harsh for the human body to accept, and has some serious side effects – not the least of which is its tendency to raise blood pressure.

q       And third. Dr. Nixon’s studies are being done with the complete complex, not with isolated ellagic acid. If you want the same results, you need to use the same supplement.

And as for those companies selling some form of berry-based ellagitannin complex and either calling it ellagic acid or claiming that it contains ellagic acid…don’t be fooled. It isn’t ellagic acid, and it doesn’t contain any. The fact of the matter is that ellagic acid itself is not naturally present in plants. Instead, polymers of gallic acid and hexahydroxydipenoyl (HHDP) are linked to glucose centers to form the class of compounds known as ellagitannins. Ellagic acid is formed when the HHDP group is cleaved from the tannin molecule and spontaneously rearranges – as happens in the digestive tract.

The bottom line is that it is the ellagitannins that are present in various fruits – not the ellagic acid. Understand, that when researchers refer to the ellagic acid content of foods, they are referring to the amount of ellagic acid that can be derived from a food-based supplement. That’s entirely different than saying the supplement contains ellagic acid.

Why does this matter?

Well, for three reasons:

1.        If the company selling the supplement truly doesn’t know what’s in the product they’re selling, why would you want to buy from that company in the first place?

2.        It they do know, and they’re willing to lie to you for “marketing purposes” why would you trust anything they say?

3.       And finally, when you understand that it’s really the ellagitannins that you’re after (and not the ellagic acid), then you realize that the source of your ellagitannins is vital – since the source will determine the exact mix of ellagitannins and how effective that mix is. That means that you want to choose a source that matches the source used in all the cancer studies – if you want the same results, that is.

The bottom line is you don’t want to buy your supplements from some “sidewalk peddler” who doesn’t have a clue about what they’re selling.

The Cure for Cancer?

Are ellagitannins the cure for cancer? No, of course not. But they are an important piece of the puzzle. You still want to do all parts of the Baseline of Health.

q       You want to build your immune system. Your immune system is your body’s prime defense against cancer.

q       You want to detox your liver and clean your blood – make them hostile to the presence of cancer.

q       You still want to alkalinize your body. Cancer thrives in an acid environment.

q       You still want to maximize nutrition levels

q       You still want to include a full spectrum antioxidant that contains known anti-carcinogens such as green tea, alpha lipoic acid, selenium, lycopene, and curcumin. They all work synergistically with red raspberry ellagitannins – making them that much more effective.

What Source

As we’ve already discussed, the source of ellagitannins that you use matters

q       First of all, the availability to the body of ellagic acid from dietary sources has only been confirmed with red raspberries. Other foods such as strawberries, pomegranates, and walnuts contain far lesser amounts of ellagic acid producing ellagitannins – and, on top of that, their bioavailability has not been confirmed. In other words, you want a red raspberry source.

q       The Meeker red raspberry is the single best source of ellagic acid producing ellagitannins. In other words, you want to use the Meeker variety.

q       And finally, if you want to be guaranteed that you duplicate Dr. Nixon’s results in your own body, then you need to use the ellagitannin source that he uses. Initially, all of Dr. Nixon’s studies were done with raspberry puree; he now uses seed flour from Meeker red raspberries for some of his testing because the seed flour has a much higher concentration of the ellagitannins than the fruit itself.

The bottom line is that the people who provide Dr, Nixon with his Meeker red raspberry seed flour product are the same people who provide Healing the Globe with theirs. It’s the same product. Two capsules, twice a day, provide 40 mg of ellagitannins – equivalent to the amount of ellagitannins found in one cup of fresh red raspberries.